GnRH Research Information

GnRH-Research-Information

Product Information

All of us know how important hormones are and the vital role they play in transferring signals and information from one set of cells to another. They are secreted by one of the glands that make up the endocrine system. GnRH is one such hormone that is produced in the hypothalamus (a part of the endocrine system) region of the brain.

Isolated in the early 1970s, GnRH (gonadotropin-releasing hormone) is said to be one of the earliest of hormones to be synthesized and released within the hypothalamus. The credit of discovery goes to two Nobel laureates Guillemin and Schally.

GnRH or Gonadotropin-Releasing Hormone (Triptorelin): Product Information

GnRH is a  poly peptide that is made up of 10 amino acids and is important for the production of sex hormones in the body. From the hypothalamus, it moves into the bloodstream and reaches the pituitary gland and gets attached to certain receptors. Once this happens, it triggers the gland to produce two more hormones: LH (luteinizing hormone) and FSH (follicle-stimulating hormone). These are known as the gonadotrophic hormones, which stimulate the reproductive organs to secrete Testosterone, estrogen, and progesterone.

GnRH Mechanism of action

FSH stimulates the growth of eggs in the ovaries and also leads to the production of estrogen and in males, LH stimulates the production of testosterone. When estrogen is produced, it signals the pituitary gland to make more LH and release FSH more slowly. LH is responsible for the mature egg being released by the ovary. When ovulation results, there is a drop in both the hormones.

Thus we see that GnRH governs the sexual physiology of men and women. However, the GnRH secretion is different for both. GnRH secretion is pulsatile, that is- the frequency at which it is secreted varies. In males, this is secreted at a constant frequency, whereas in females the frequency varies during the menstrual cycle and just before ovulation, the production of GnRH increases.

Chemical Information

pyroGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2

Pharmacokinetic and other information

Since GnRH is associated with the production of sexual hormones, it is not very active during childhood; however once puberty or adolescence is reached and the reproductive period begins, it gains momentum and plays an important role in the reproductive function. It again becomes inactive when a woman becomes pregnant and activity is also disrupted when the hypothalamus and pituitary glands dysfunction.

The Biochemical Process

Many neurons and neuro transmitters are involved in the regulation of GnRH neurons. Some help in the stimulation and inhibition of LH release. That is why GnRH is essentially considered a neuro- hormone.

GnRH Antagonists and Agonists

No sooner than Guillemin and Schally discovered GnRH, they tried to modify the peptide to help stimulate and block variants for various procedures– the result was a new avenue of therapy with GnRH antagonists and agonists.

GnRH agonists and antagonists belong to a group of hormone drugs called GnRH analogues. These analogues are used in infertility treatment. The use of GnRH agonists is a big advancement in hormone therapy and is used to stop the production of testosterone and estrogen. GnRH agonist injections are given every day—these force the pituitary gland to stop producing hormones.

GnRH antagonists are very similar to the naturally occurring hormone GnRH that is made in the hypothalamus, but as the name suggests it has an antagonistic effect. Like GnRH it is also a peptide molecule that is made up of many amino-acids. When it binds to the GnRH receptors, it prevents GnRH from going into action. As a result it blocks the release of LH and FSH in the pituitary glands, thus suppressing the production of testosterone and estrogen. This is invaluable during fertility treatments, especially when preparing for in-vitro fertilization, when it is needed to control the amounts of LH and FSH. GnRH antagonists are usually administered in the form of an intramuscular or subcutaneous injection.

Shutting down the pituitary gland is essential to proceed with an infertility procedure.

Although the end result is the same, the GnRH antagonists and agonists work slightly differently.  While the GnRH antagonist ensures an immediate drop in LH and FSH production, GnRH agonists take some time before they bring about a drop in the secretion of LH and FSH.

After the discovery of GnRH, any research that was done was directed toward treating infertility, but with synthetic GnRH proving to be rather resourceful, the focus of diagnosis and treatment was turned toward endocrine disorders and cancer.

Other potential medical uses of GnRH

Recently there have been newspaper reports that the hypothalamus plays a role in aging and researchers were focusing on the effect of GnRH on aging. Scientists found that it was possible for GnRH to reach the brain from the periphery, indicating that the hormone could have some anti-aging properties. Of course this does require additional study, but the prospects do seem exciting.

TO PURCHASE

If you would like to purchase GnRH (Triptorelin) for research, you can visit: https://peptidepros.net/product/gnrh-triptorelin-1mg/

POSTING DISCLAIMER

The info provided herein is strictly for the advancement of research and disbursement of knowledge relating to GnRH (Triptorelin).  It is meant solely  for any qualified researchers looking to find potential applications or possible health benefits yet to be discovered for GnRH (Triptorelin).   This post is meant for informational use only and is in no way considered instructional, in fact, no dosage or other similar information is provided.  The facts contained herein have been gathered from various studies and tests conducted in sanctioned and/or controlled medical research facilities, Universities and laboratories, using in-vitro techniques or when approved animal and human subjects.  However, due to the fact that this peptide is not approved for human consumption, we emphatically state that you should gain the necessary legal approvals prior to conducting any research on animals or humans.  The following information is meant ONLY to share results from certified tests with other qualified researchers to further the understanding of this peptide.  This post is not to be construed as an advertisement or inducement to ingest this product.  Peptide Pros is opposed to  the use of peptides for recreational or cosmetic use unless otherwise approved by the FDA or a similar governing body designated to do so.

Ipamorelin Research Information

Ipamorelin Research Information

Product Description

Ipamorelin is a growth hormone releasing peptide or a GHRP, which is similar to GHRP2 and GHRP6 that was developed by Novo Nordisk. It is a pentapeptide, which is composed of 5 amino acids, which cause a significant release of growth hormone by the anterior pituitary gland. It is also known for its anti-ageing benefits.

Ipamorelin Product Information

1.     Chemical Information

The peptide has a chemical formula of C38H49N9O5, and the molecular massof this peptide is 711.85296.

2.     Systematic Name

IpoMarelin; IpaMorelin Acetate; Aib-His-D-2-Nal-D-Phe-Lys-NH2

3.     Pharmacokinetic and other information

Ipamorelin or Ipamorelin acetateis currently ‘unscheduled’ by the United States government meaning that it is not regulated by law.

Ipamorelin or Ipamorelin acetate has a half-life, or the time taken for the compound to lose half of its potency value, is two hours.

Ipamorelin or Ipamorelin acetate: The Biochemical Process

The mechanical dynamics of the Ipamorelin or Ipamorelin acetate process present themselves primarily and directly to the central nervous system of the body. Specifically speaking, research involving living non human subjects,who were carefully given monitored dosages of the peptide showed Ipamorelin acetate’s half-life by a huge amount. This activation has led scientists to discover that the reaction itself actually takes control of or restricts the particular signals sent by the brain to the body. The signals that are given are quite specific, relating to the blood flow of the body and any areas of the body that are experiencing inflammation. Alternatively, when the switch to these receptors has been done, the brain is then able to successfully moderate the signals relating to these specific issues.

Ipamorelin or Ipamorelin acetate and the Synthesis of Proteins

One of the supposed benefits of Ipamorelin or Ipamorelin acetate involves the induction of sleep in a person. Scientific studies have shown that the presence of Ipamorelin or Ipamorelin acetate has a tendency to enhance the amount of proteins that an animal test subject can create by blocking the natural process of the degradation of the cell. Another advantage that it has been said to have revolves around the idea of enhancing the metabolism, and how the peptide shows an ability to speed up the process, in which the metabolism of the person is enhanced speedily. This in turn allows the bodies of any subject to burn through fat more efficiently. The other benefits that can be possibly derived include a speedy rate of injury recovery, a more efficient process of muscular growth and an increase in bone density.

Hemorrhagic Shock and Ipamorelin or Ipamorelin acetate Interaction

The design of Ipamorelin or Ipamorelin acetate is such that itmotivates and stimulates the reflexes of the nerves within the brain and it also regulates any organic flow of blood that may result in actual organ failure, which would result from genuine hemorrhagic shock. The shock, which is hemorrhagic, is the result of what is referred to as a ‘lower tissue perfusion’ or the administration of oxygen to the tissue manually through a variety of methods, which becomes worse invariably due to increased lack of oxygen to the region over time.

There are four classifications or types of hemorrhagic shock:

  • Septic (or ‘vasogenic’)
  • Cardiogenic
  • Neurogenic
  • Hypovolemic

Since science knows that two individual cells do not show the same responses as the other, as has been observed on the level of a cell, it is a bit tough to deal with this condition.

Current related research and findings regarding Ipamorelin or Ipamorelin acetate

While there has been a several research studies conducted in relation to Ipamorelin or Ipamorelin acetate and its overall functionality, theorized benefits, and negative side effects, and operational mechanics, it needs to be emphasized that ALL of the research that has been conducted along with its resultant findings hasbeen the product of studies ononly animals.  Ipamorelin or Ipamorelin acetate is notentirely intended for the use of personal use at the moment. Therefore, any observations or findings relating to the overall functionality, theoretical benefits, mechanics, or negative side effects of Ipamorelin or Ipamorelin acetate should only be contained to the restrictions of a strictly controlled environment such as a laboratory or a medical research facility.

Developmental information regarding Ipamorelin or Ipamorelin acetate

Ipamorelin or Ipamorelin acetate (which is also known as Geref) is known as Growth Hormone Releasing Hormones or GHRH. Ipamorelin or Ipamorelin acetatehas a short half-life of about half an hour. Many scientists have said that the half-life of Ipamorelin or Ipamorelin acetate is considered to be way more natural as it is said to produce a short pulse of Human Growth Hormone.

Despite the fact that plenty of research has been carried out on Ipamorelin or Ipamorelin acetate in relation to how it functions and the benefits that it gives, it should be emphasized that Ipamorelin or Ipamorelin acetate, at this point in time, is still just intended for the scientific study of some of its aspects. Because of this, any findings or observations relating to Ipamorelin or Ipamorelin acetate should solely be the product of study performed in a medical research facility or a laboratory under strict conditions.Therefore, communicatewith your health care provider before administering any supplement or medication at any time for your own safety, and make sure that you follow the instructions given by both your physician as well as the instructions mentioned on the cover of Ipamorelin or Ipamorelin acetate.

TO PURCHASE

If you would like to purchase Ipamorelin for research, you can visit: https://peptidepros.net/product/ipamorelin-2mg/

POSTING DISCLAIMER

The info provided herein is strictly for the advancement of research and disbursement of knowledge relating to Ipamorelin.  It is meant solely  for any qualified researchers looking to find potential applications or possible health benefits yet to be discovered for Ipamorelin.   This post is meant for informational use only and is in no way considered instructional, in fact, no dosage or other similar information is provided.  The facts contained herein have been gathered from various studies and tests conducted in sanctioned and/or controlled medical research facilities, Universities and laboratories, using in-vitro techniques or when approved animal and human subjects.  However, due to the fact that this peptide is not approved for human consumption, we emphatically state that you should gain the necessary legal approvals prior to conducting any research on animals or humans.  The following information is meant ONLY to share results from certified tests with other qualified researchers to further the understanding of this peptide.  This post is not to be construed as an advertisement or inducement to ingest this product.  Peptide Pros is opposed to  the use of peptides for recreational or cosmetic use unless otherwise approved by the FDA or a similar governing body designated to do so

CJC-1295 with DAC Research Information

Research-Product-CJC-1295-with-DAC-610x310

Product Description

CJC-1295 with DAC is a thirty amino acid based peptide, which is currently being researched for a variety of benefits, including the increase in metabolism. Invented by Canadian biotechnology company, Conjuchem, it has the ability to lengthen the half life of active agents, which has to do with a process called bioconjugation. During studies, it was discovered that, not only did CJC-1295 with DAC help in the water regulation and balance in the body, but it also gives relief from pain. Studies have also shown impressive results regarding the positive effects of this peptide on conditions such as indigestion and body pain. Here, we will discuss CJC-1295 with DAC in full detail by discussing them and the makeup of the peptide which results in providing a variety of benefits to the human being.

CJC-1295 with DAC Product Information

1.    Chemical Information

The peptide has a chemical formula of C152H252N44O42, and the molecular weight of this peptide is 3367.2.

2.    Systematic Name

CJC1295/DAC, CJC-1295 with DAC, CJC 1295

3.    Pharmacokinetic and other information

CJC-1925 with DAC is currently ‘unscheduled’ by the United States government meaning that it is not regulated by law.

CJC has a half-life, or the time taken for the compound to lose half of its potency value, is two hours.

CJC-1295 with DAC: The Biochemical Process

The mechanical dynamics of the CJC-1295 process present themselves primarily and directly to the central nervous system of the body. Specifically speaking, research involving living non human subjects, who were carefully given monitored dosages of the peptide showed GHRH1-29’s half-life by a major amount. This activation has led scientists to discover that the reaction itself actually takes control of or restricts the particular signals sent by the brain to the body. The signals, which are given, are quite specific, relating to the blood flow of the body and any areas of the body that are experiencing inflammation.Alternatively, when the switch to these receptors has been done, the brain is then able to successfully moderate the signals relating to these specific issues.

CJC-1295 with DAC and the Recovery from injury

The overall functionality of the CJC 1295 With DAC has led scientific study based on live animal test subjects to determine that CJC-1295 with DAC can be the source of a host of possible benefits.  Most of these advantages relate to an increase in the synthesis of proteins, which is directly correlated to the ability of the peptide to increase the half-life of GHRH1-29 by a major amount. Some of these advantages related to it include an increase in the density of the bones, a boost in the proliferation of the muscular tissue, a more efficient method of weight loss, and a faster way to recover from injury.It has also been determined that the functionality of the peptide can block programmed cell death, increase the bioactivity in the body, and also boost the rate of lipolysis.

Hemorrhagic Shock and GHRH1-29 Interaction

CJC-1295 with DAC, by design, motivates and stimulatesreflexes of the nerves within the brain and it regulates any organic flow of blood that may result in actual organ failure, which would result from genuine hemorrhagic shock. The shock, which is hemorrhagic, is the result of what is referred to as a ‘lower tissue perfusion’ or the administration of oxygen to the tissue manually through a variety of methods, which becomes worse invariably due to increased lack of oxygen to the region over time.

There are four classifications or types of hemorrhagic shock:

  • Septic (or ‘vasogenic’)
  • Cardiogenic
  • Hypovolemic
  • Neurogenic

Since science knows that no two individual cells show the same responses, as has been observed on the level of a cell, it is a bit difficult to deal with this condition.

Current related research and findings regarding CJC-1925 with DAC

While there has been a several research studies conducted in relation to CJC-1295 with DAC and its overall functionality, theorized benefits, and negative side effects, and operational mechanics, it needs to be emphasized that ALL of the research that has been conducted along with its resultant findings has been the product of studies on animals alone.  CJC-1295 with DAC is solely intended for the use of scientific study at this time. Therefore, any observations or findings relating to CJC-1295 with DAC’s overall functionality, theoretical benefits, mechanics, or negative side effects should only be contained to the restrictions of a strictly controlled environment such as a laboratory or a medical research facility.

Developmental information regarding CJC-1295 with DAC

CJC-1295 DAC and CJC-1295 (which is also known as Modified GRF 1-29) are both known as GHRH or Growth Hormone Releasing Hormones. They act on the body in a similar fashion, but the difference between the two peptides is based on the span of the half-life. Modified GRF 1-29 and Sermorelin or CJC-1295 with DAC has a short half-life of about half an hour, while CJC-1295 with DAC has a half-life that can last up to around eight days. Many scientists have said that the half life of Modified GRF 1-29 and Sermorelin is considered to be way more natural as they are said to produce a short pulse of Human Growth Hormone.

Despite the fact that plenty of research has been carried out on CJC-1295 with DAC in relation to how it functions and the benefits that it gives, it should be emphasized that CJC-1925 with DAC, at this point in time, is still just intended for scientific study. Because of this, any findings or observations relating to CJC-1295 with DAC should solely be the product of study performed in a medical research facility or a laboratory under strict conditions. Therefore, communicate with your health care provider before administering any supplement or medication at any time for your own safety, and make sure that you follow the instructions given by both your physician as well as the instructions mentioned on the cover of CJC-1295 with DAC.

TO PURCHASE

If you would like to purchase CJC-1295 with DAC for research, you can visit: https://peptidepros.net/product/cjc-1295-with-dac-2mg/

POSTING DISCLAIMER

The info provided herein is strictly for the advancement of research and disbursement of knowledge relating to CJC-1295 with DAC.  It is meant solely  for any qualified researchers looking to find potential applications or possible health benefits yet to be discovered for CJC-1295 with DAC.   This post is meant for informational use only and is in no way considered instructional, in fact, no dosage or other similar information is provided.  The facts contained herein have been gathered from various studies and tests conducted in sanctioned and/or controlled medical research facilities, Universities and laboratories, using in-vitro techniques or when approved animal and human subjects.  However, due to the fact that this peptide is not approved for human consumption, we emphatically state that you should gain the necessary legal approvals prior to conducting any research on animals or humans.  The following information is meant ONLY to share results from certified tests with other qualified researchers to further the understanding of this peptide.  This post is not to be construed as an advertisement or inducement to ingest this product.  Peptide Pros is opposed to  the use of peptides for recreational or cosmetic use unless otherwise approved by the FDA or a similar governing body designated to do so.