GHRP-6 Research Information

Research-GHRP-6

Product Description

GHRP-6, better known as Growth hormone releasing hexapeptide 6, is a well-known peptide that’s widely used for its Growth Hormone (GH) releasing properties. It’s an amino acid peptide used to increase GH production. It falls in Human Growth Hormone secretagogues category. The other peptides that come under the same category are Ipamorelin, GHRP-2, and Hexarelin. GHRP-6 sends a message to the pituitary gland to begin secreting the Growth Hormone and this is the most critical function of GHRP-6. This protein peptide helps in weight loss. In most case, it also helps build lean muscles. GHRP-6 is usually used as an alternative for GHRP, as the former is known to have properties that somehow work towards increasing appetite. It also helps to minimize inflammation and aids in the healing of injury. Here, we are going to take a closer look at GHRP-6, its benefits and other details. We’ll look at a few studies conducted on this peptide, its composition and functions.

GHRP-6 or Growth Hormone Releasing Hexapeptide – 6: Product Information

  1. Chemical Information

GHRP-6 has a molecular mass of 873 Dalton. The molecular formula of GHRP-6 is C46H56N12O6.

  1. Systematic Name (IUPAC)

L-histidyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-Lysinamide

  1. Pharmacokinetic and other information

The use of GHRP-6 has not been given legal approval yet or received permission for medical use as such. It’s a new compound and needs to be studied extensively. The peptide is still under medical trials. GHRP-6 hasn’t received any official approval for sale either. However, scientists believe that they can determine the effects GHRP-6 in the next few years with extensive research and findings.

A number of studies have been conducted on GHRP-6 to determine the saturation levels for usage. The peptide shows variations in the half-life duration, ranging between 15 minutes to an hour. The increase in GH levels maximizes around half an hour post the administration.

GHRP-6: The Biochemical Process

GHRP-6 is a peptide that is also referred to as the protein hormone, sends messages to the pituitary gland to start the secretion of the Growth Hormone. The process of releasing the GH is enabled by a number of synthetic secretagogues. When GH levels go up, it’s followed by an increased level of IGF-1 which is secreted by the liver. This combined action leads to the loss of fat cells. There have been instances where the usage of GHRP-6 has resulted in muscle gain as well.

The increased levels in GH and IGF-1 provide ideal body conditions for fitness trainers, athletes and for anyone else who works out and engages in any form of physical activity.

There are also instances where GHRP-6 and insulin have been used together to produce a spike in GH release, as opposed to use of GHRP-6 alone. However, if one consumes carbs or dietary fats during the phase of GH secretagogues release, then the rate of GH release is negatively impacted. So the use of GHRP-6 needs to be monitored to get the best results.

GHRP-6 and Ghrelin

The use of GHRP-6 is associated with a spike in appetite. This happens when GHRP-6 seems to imitate another peptide – Ghrelin.

Ghrelin is most times linked to insulin resistance and obesity. Though it seems that GHRP-6 copies the function of Ghrelin, it works against Ghrelin in reality. This process results in greater appetite and makes one eat more than usual. This phenomenon is great when you are in the bulking phase of bodybuilding.

However, studies show that if you consume more than 150 mcg, there will spike in appetite. This will become too much for the user and would result in him eating more than required. Therefore, one needs to monitor the dosage carefully.

If administered in the right doses, not only does GHRP-6 help in bulking, but is also known to result in increased strength and vigour.

GHRP-6, unlike most other peptides, is known to minimize inflammation and helps cure tendonitis. Also, it strengthens and increases lean muscles. These advantages make GHRP-6 a preferred peptide to increase GH levels. It gives the users the feeling of tapping into the body’s capability to get the desired results rather than using artificial agents to do the same.

GHRP-6 Handling

GHRP-6 is mostly available in small vials of 5 mg each. This comes as a lyophilized powder form and is stable at room temperature.  Once diluted with specific liquids such as bacteriostatic or sterile water, they need to be refrigerated to maintain the peptide’s properties.

Related Research and Findings of GHRP-6

Many researchers have agreed that GHRP-6 increases the production of growth hormone which promote the building of lean body mass and reduce fat deposits.

Recent study, also go on to show that GHRP-6 show signs of having a neuroprotective effect. It works to aid the caspase-independent pathway which in turn aids in removal of faulty cells from the organism. GHRP-6 was shown to alter the process of glutamate-induced cell death. This goes on to show that GHRP-6 has a neuroprotective effect by blocking the pathway of caspase-independent cell death.

This peptide seems to have a lot more properties than just that of increasing GH levels. We need extensive research to shed light on what those properties are and how they’ll benefit us in future.

TO PURCHASE

If you would like to purchase GHRP-2 for research, you can visit: https://peptidepros.net/product/ghrp-6/

POSTING DISCLAIMER

The info provided herein is strictly for the advancement of research and disbursement of knowledge relating to GHRP-6.  It is meant solely  for any qualified researchers looking to find potential applications or possible health benefits yet to be discovered for GHRP-6.   This post is meant for informational use only and is in no way considered instructional, in fact, no dosage or other similar information is provided.  The facts contained herein have been gathered from various studies and tests conducted in sanctioned and/or controlled medical research facilities, Universities and laboratories, using in-vitro techniques or when approved animal and human subjects.  However, due to the fact that this peptide is not approved for human consumption, we emphatically state that you should gain the necessary legal approvals prior to conducting any research on animals or humans.  The following information is meant ONLY to share results from certified tests with other qualified researchers to further the understanding of this peptide.  This post is not to be construed as an advertisement or inducement to ingest this product.  Peptide Pros is opposed to  the use of peptides for recreational or cosmetic use unless otherwise approved by the FDA or a similar governing body designated to do so.

GHRP-2 Research Information

Research-GHRP-2

Product Description

GHRP-2 or Growth Hormone Releasing Peptide – 2 is afamily of peptides, which is currently being researched for a variety of benefits, including growth. Invented twenty years ago as synthetic metenkephalin-derived oligopeptides, it has been used for several years and has also been used for other purposes such as treating hormone deficiencies, and the like. It is not a peptide, which was invented yesterday, but something that has been known to have had benefits for many people over the years.

GHRP-2 or Growth Hormone Releasing Peptide – 2 Product Information

1.     Chemical Information

The peptide has a chemical formula of C45H55N9O6, and the molecular weight of this peptide is 817.97.

2.     Systematic Name

D-Alanyl-3, (2-naphthyl), D-alanyl, L-alanyl, L-tryptophyl, D-phenylalanyl, L-lysinamide

3.     Pharmacokinetic and other information

GHRP-2 or Growth Hormone Releasing Peptide – 2is currently ‘unscheduled’ by the United States government meaning that it is not regulated by law.

GHRP-2 or Growth Hormone Releasing Peptide – 2 has a half-life, or the time taken for the compound to lose half of its potency value, is two hours.

GHRP-2 or Growth Hormone Releasing Peptide – 2: The Biochemical Process

The half-life of GHRP-2 or Growth Hormone Releasing Peptide – 2 is quite short. The chemical processes carried out while processing GHRP-2 or Growth Hormone Releasing Peptide – 2 present themselves to the central nervous system of the body. Specifically speaking, research involving living non human subjects,who were carefully given monitored dosages of the peptide showed GHRP-2 or Growth Hormone Releasing Peptide – 2’s half-life by a significant amount. This activation of the hormone has led scientists to conclude that the reaction itself actually takes charge of or restricts the particular signals sent by the brain to the body. The signals,which are given, are quite specific, relating to the blood flow of the body and any areas of the body that are experiencing problems such as inflammation.Alternatively, when the switch to these receptors has been done, the brain is then able to successfully moderate the signals relating to these specific issues. However, upon research, it was found that the results vary from one person to another.

GHRP-2 or Growth Hormone Releasing Peptide – 2 and the release of the growth hormones

One of the supposed benefits of GHRP-2 or Growth Hormone Releasing Peptide – 2involves the reduction of inflammation in an individual. Scientific studies have shown that the presence of GHRP-2 or Growth Hormone Releasing Peptide – 2has a tendency to release growth hormones that are secreted in the body. It can also increase the influx of calcium ions in the body. This in turn releases more growth hormones and helps in the growth of an individual. Aside from that, it has known to be effective in helping the growth of an individual.

Hemorrhagic Shock and GHRP-2 or Growth Hormone Releasing Peptide – 2 Interaction

The design of GHRP-2 or Growth Hormone Releasing Peptide – 2is such that itstimulates and motivates the reflexes of the nerves within the brain and it also regulates any organic blood flowthat may result inthe actual failure of an organ, which would result from actual hemorrhagic shock. The shock, which is hemorrhagic, is the result of what is referred to as the administration of oxygen or the ‘lower tissue perfusion’ to the tissue manually using different methods, which often becomes worse invariably due to increased lack of oxygen being sent to the area over time.

There are four classifications or types of hemorrhagic shock:

  • Cardiogenic
  • Neurogenic
  • Hypovolemic
  • Septic (or ‘vasogenic’)

Since science knows that two individual cells do not show the same responses as the other, as has been observed on the level of a cell, it is a bit tough to deal with this condition.

Current related research and findings regarding GHRP-2 or Growth Hormone Releasing Peptide – 2

While there has been a several research studies conducted in relation to GHRP-2 or Growth Hormone Releasing Peptide – 2and its overall functionality, theorized benefits, and negative side effects, and operational mechanics, it needs to be emphasized that ALL of the research that has been conducted along with its resultant findings hasbeen the product of studies of both animals as well as human beings.  GHRP-2 or Growth Hormone Releasing Peptide – 2 is notentirely intended for the use of personal use at the moment. Therefore, any observations or findings relating to the overall functionality, theoretical benefits, mechanics, or negative side effects of GHRP-2 or Growth Hormone Releasing Peptide – 2should only be contained to the restrictions of a strictly controlled environment such as a laboratory or a medical research facility.

Developmental information regarding GHRP-2 or Growth Hormone Releasing Peptide – 2

GHRP-2 (which is also known as Growth Hormone Releasing Peptide – 2) isknown as Growth Hormone Releasing Hormones or GHRH. GHRP-2 or Growth Hormone Releasing Peptide – 2has a short half-life of about half an hour. Many scientists have said that the half-life of GHRP-2 or Growth Hormone Releasing Peptide – 2 is considered to be way more natural as it is said to produce a short pulse of Human Growth Hormone.

Despite the fact that plenty of research has been carried out on GHRP-2 or Growth Hormone Releasing Peptide – 2 in relation to how it functions and the benefits that it gives, it should be emphasized that GHRP-2 or Growth Hormone Releasing Peptide – 2, at this point in time, is still just intended for the scientific study of some of its aspects. Because of this, any findings or observations relating to GHRP-2 or Growth Hormone Releasing Peptide – 2should solely be the product of study performed in a medical research facility or a laboratory under strict conditions.  Therefore, communicate with your health care provider before administering any supplement or medication at any time for your own safety, and make sure that you follow the instructions given by both your physician as well as the instructions mentioned on the cover of GHRP-2 or Growth Hormone Releasing Peptide – 2.

TO PURCHASE

If you would like to purchase GHRP-2 for research, you can visit: https://peptidepros.net/product/ghrp-2/

POSTING DISCLAIMER

The info provided herein is strictly for the advancement of research and disbursement of knowledge relating to GHRP-2.  It is meant solely  for any qualified researchers looking to find potential applications or possible health benefits yet to be discovered for GHRP-2.   This post is meant for informational use only and is in no way considered instructional, in fact, no dosage or other similar information is provided.  The facts contained herein have been gathered from various studies and tests conducted in sanctioned and/or controlled medical research facilities, Universities and laboratories, using in-vitro techniques or when approved animal and human subjects.  However, due to the fact that this peptide is not approved for human consumption, we emphatically state that you should gain the necessary legal approvals prior to conducting any research on animals or humans.  The following information is meant ONLY to share results from certified tests with other qualified researchers to further the understanding of this peptide.  This post is not to be construed as an advertisement or inducement to ingest this product.  Peptide Pros is opposed to  the use of peptides for recreational or cosmetic use unless otherwise approved by the FDA or a similar governing body designated to do so.

CJC-1295 with DAC Research Information

Research-Product-CJC-1295-with-DAC-610x310

Product Description

CJC-1295 with DAC is a thirty amino acid based peptide, which is currently being researched for a variety of benefits, including the increase in metabolism. Invented by Canadian biotechnology company, Conjuchem, it has the ability to lengthen the half life of active agents, which has to do with a process called bioconjugation. During studies, it was discovered that, not only did CJC-1295 with DAC help in the water regulation and balance in the body, but it also gives relief from pain. Studies have also shown impressive results regarding the positive effects of this peptide on conditions such as indigestion and body pain. Here, we will discuss CJC-1295 with DAC in full detail by discussing them and the makeup of the peptide which results in providing a variety of benefits to the human being.

CJC-1295 with DAC Product Information

1.    Chemical Information

The peptide has a chemical formula of C152H252N44O42, and the molecular weight of this peptide is 3367.2.

2.    Systematic Name

CJC1295/DAC, CJC-1295 with DAC, CJC 1295

3.    Pharmacokinetic and other information

CJC-1925 with DAC is currently ‘unscheduled’ by the United States government meaning that it is not regulated by law.

CJC has a half-life, or the time taken for the compound to lose half of its potency value, is two hours.

CJC-1295 with DAC: The Biochemical Process

The mechanical dynamics of the CJC-1295 process present themselves primarily and directly to the central nervous system of the body. Specifically speaking, research involving living non human subjects, who were carefully given monitored dosages of the peptide showed GHRH1-29’s half-life by a major amount. This activation has led scientists to discover that the reaction itself actually takes control of or restricts the particular signals sent by the brain to the body. The signals, which are given, are quite specific, relating to the blood flow of the body and any areas of the body that are experiencing inflammation.Alternatively, when the switch to these receptors has been done, the brain is then able to successfully moderate the signals relating to these specific issues.

CJC-1295 with DAC and the Recovery from injury

The overall functionality of the CJC 1295 With DAC has led scientific study based on live animal test subjects to determine that CJC-1295 with DAC can be the source of a host of possible benefits.  Most of these advantages relate to an increase in the synthesis of proteins, which is directly correlated to the ability of the peptide to increase the half-life of GHRH1-29 by a major amount. Some of these advantages related to it include an increase in the density of the bones, a boost in the proliferation of the muscular tissue, a more efficient method of weight loss, and a faster way to recover from injury.It has also been determined that the functionality of the peptide can block programmed cell death, increase the bioactivity in the body, and also boost the rate of lipolysis.

Hemorrhagic Shock and GHRH1-29 Interaction

CJC-1295 with DAC, by design, motivates and stimulatesreflexes of the nerves within the brain and it regulates any organic flow of blood that may result in actual organ failure, which would result from genuine hemorrhagic shock. The shock, which is hemorrhagic, is the result of what is referred to as a ‘lower tissue perfusion’ or the administration of oxygen to the tissue manually through a variety of methods, which becomes worse invariably due to increased lack of oxygen to the region over time.

There are four classifications or types of hemorrhagic shock:

  • Septic (or ‘vasogenic’)
  • Cardiogenic
  • Hypovolemic
  • Neurogenic

Since science knows that no two individual cells show the same responses, as has been observed on the level of a cell, it is a bit difficult to deal with this condition.

Current related research and findings regarding CJC-1925 with DAC

While there has been a several research studies conducted in relation to CJC-1295 with DAC and its overall functionality, theorized benefits, and negative side effects, and operational mechanics, it needs to be emphasized that ALL of the research that has been conducted along with its resultant findings has been the product of studies on animals alone.  CJC-1295 with DAC is solely intended for the use of scientific study at this time. Therefore, any observations or findings relating to CJC-1295 with DAC’s overall functionality, theoretical benefits, mechanics, or negative side effects should only be contained to the restrictions of a strictly controlled environment such as a laboratory or a medical research facility.

Developmental information regarding CJC-1295 with DAC

CJC-1295 DAC and CJC-1295 (which is also known as Modified GRF 1-29) are both known as GHRH or Growth Hormone Releasing Hormones. They act on the body in a similar fashion, but the difference between the two peptides is based on the span of the half-life. Modified GRF 1-29 and Sermorelin or CJC-1295 with DAC has a short half-life of about half an hour, while CJC-1295 with DAC has a half-life that can last up to around eight days. Many scientists have said that the half life of Modified GRF 1-29 and Sermorelin is considered to be way more natural as they are said to produce a short pulse of Human Growth Hormone.

Despite the fact that plenty of research has been carried out on CJC-1295 with DAC in relation to how it functions and the benefits that it gives, it should be emphasized that CJC-1925 with DAC, at this point in time, is still just intended for scientific study. Because of this, any findings or observations relating to CJC-1295 with DAC should solely be the product of study performed in a medical research facility or a laboratory under strict conditions. Therefore, communicate with your health care provider before administering any supplement or medication at any time for your own safety, and make sure that you follow the instructions given by both your physician as well as the instructions mentioned on the cover of CJC-1295 with DAC.

TO PURCHASE

If you would like to purchase CJC-1295 with DAC for research, you can visit: https://peptidepros.net/product/cjc-1295-with-dac-2mg/

POSTING DISCLAIMER

The info provided herein is strictly for the advancement of research and disbursement of knowledge relating to CJC-1295 with DAC.  It is meant solely  for any qualified researchers looking to find potential applications or possible health benefits yet to be discovered for CJC-1295 with DAC.   This post is meant for informational use only and is in no way considered instructional, in fact, no dosage or other similar information is provided.  The facts contained herein have been gathered from various studies and tests conducted in sanctioned and/or controlled medical research facilities, Universities and laboratories, using in-vitro techniques or when approved animal and human subjects.  However, due to the fact that this peptide is not approved for human consumption, we emphatically state that you should gain the necessary legal approvals prior to conducting any research on animals or humans.  The following information is meant ONLY to share results from certified tests with other qualified researchers to further the understanding of this peptide.  This post is not to be construed as an advertisement or inducement to ingest this product.  Peptide Pros is opposed to  the use of peptides for recreational or cosmetic use unless otherwise approved by the FDA or a similar governing body designated to do so.

PT-141 (Bremelanotide) Research Information

PT-141-Bremelanotide-Product-Research

Product Description

Formerly known as PT-141, Bremelanotide is a recurrent peptide which is still being researched for a variety of benefits including female sexual dysfunction. Derived from the peptide hormone referred to as Melatonin II it was first created to be used for ‘sunless’ tanning. During studies it was discovered that, not only did Bremelanotide darken the skin but also stimulated sexual interest and arousal in women. Studies have also shown impressive results regarding the positive effects of this peptide on conditions such as reperfusion injury and hemorrhagic shock Here we will discuss Bremelanotide more extensively, discussing the details and makeup of the peptide which results in providing a variety of benefits to the human being.

PT-141 (Bremelanotide) Product Information

1.    Chemical InformationBremelanotide (PT 141) Molecular Structure

Bremelanotide contains a molecular mass of 1025.2 grams per mol. It’s chemical formula is C50H68N14O10.

2.    Systematic Name (IUPAC)

(3S 6S 9R 12S 15S)-15-[(N-acetyl-L-norleucyl)amino]- 9-bynzyl-6-{3-[(diaminomethylidine)amino]propyl}-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexaa zacyclotricosane-23-carboxylic acid

3.    Pharmacokinetic and other information

Bremelanotide is currently ‘unscheduled’ by the United States government meaning that PT-141 is not regulated by law.

Bremelanotide has a half-life, or the time it takes for the compound do lose half of its potency value, is 2 hours.

Bremelanotide: The Biochemical Process

The mechanical dynamics of the PT-141 process present themselves primarily and directly to the body’s central nervous system. Specifically speaking, research involving non-human living subjects which were administered carefully monitored dosages of the peptide showed a growth in the stimulation and ‘ignition’, if you will, of the MC-4R and MC-3R melanocortin receptors themselves. This activation has led science to discover that the reaction itself actually takes control of and/or constrains particular signals emitted by the brain to the body. The signals which are inhibited are quite specific, relating to the body’s blood flow and any areas of the body experiencing inflammation. In other words, when the switch to these receptors has been flipped the brain is able to successfully moderate the signals relating to these specific issues.

Bremelanotide and Reperfusion Shock

By definition ‘reperfusion damage’ is damage caused to organ tissue which has been cut off from its blood supply by any occurrence, say a stroke for example. The damage occurs when blood flow is restored to the tissue which has been with it for so long. When tissue is deprived of the oxygen and nutrients it needs the body kicks that area into a state which can result in oxidation if blood flow is ever restored, referred to as ‘oxidative stress’. This only occurs when the body has not been eased into the healthy state properly.

The smallest of these injuries are of great detriment to the individual, as they often lead to brain injuries such as strokes or heart attacks, and can even result in complete failure of all brain function. PT-141 works on an entirely neurological level, activating the receptors which stabilize the signals sent to empower the signals related to the restriction of blood flow, easing, if not completely stopping, the chances of reperfusion shock from occurring.

Hemorrhagic Shock and PT-141 Interaction

Bremelanotide, by design, stimulates and motivates the neural reflexes within the brain, thus regulating any organic flow of blood which may cause actual organ failure which would result from actual hemorrhagic shock. Hemorrhagic shock is the result of what is referred to as a ‘lower tissue perfusion’, or the administration of oxygen to the tissue manually through a variety of methods, which invariably worsens due to increased lack of oxygen to the area over time.

There are four types, or classifications, of hemorrhagic shock:

  • Septic (or ‘vasogenic’)
  • Neurogenic
  • Hypovolemic
  • Cardiogenic

It has been proven a bit difficult to deal with this particular condition as science knows that no two individual cells demonstrate the same responses, as observed on a cellular level.

Current related research and findings regarding PT-141 (Bremelanotide)

There are some important points which should be noted regarding the study of the peptide Bremelanotide, as this substance is still in the research phase. To date all findings, theories, and conclusions have been deduced through studies done on living, non-human subjects in a completely controlled and stabilized environment. It is vehemently recommended that ANY and ALL use of PT-141 be done on a fully controlled and supervised basis ONLY.

It should also be clearly noted that a study scheduled to begin in 2007 was postponed when rises in blood pressure were found to be another side-effect, which can be dangerous in many individual cases.

Developmental information regarding Bremelanotide

Bremelanotide (PT-141) is directly derived from the peptide hormone ‘Melanotan II’. As mentioned, it was developed with full intent of marketing the product as a sunless tanning compound as it directly affected the skin-tone.

Over the course of development it was discovered to have very effective female arousal properties as well as causing erections in males on a spontaneous basis. These side-effects were not anticipated, and occurred in 90% of male subjects in the study.

In 2012 a study was conducted which administered PT-141 to premenopausal female subjects, and high-level results were reported all the way around, showing effectiveness in the treatment of a number of menopausal symptoms which had manifest, lessening them significantly.

The effects of Bremelanotide on the libido of either sex has been found to work in completely different manner when compared to enhancement drugs such as Cialis or Viagra, both of which affect blood flow to the sex organs. Rather PT-141 has been proven to stimulate sexual desire by invigorating the areas of the brain which cause sexual desire, thereby enhancing libido and performance. To date Bremelanotide has continued to be closely studied and monitored, and is currently readily available for purchase for research only at this time since it is yet to be FDA approved. Administering any supplement or medication not FDA approved may be harmful and may cause serious illness.  Peptide Pros insist that none of their products be ingested for under any circumstances.

Source:

For research purposes PT-141 (Bremelanotide) may be purchased at the Peptide Pros Shop here: https://peptidepros.net/product/pt-141/

Top 7 Myths About Peptides

Peptides-Myth-vs-fact-610x310

The purpose of this article is not to promote the recreational use of peptides, rather to debunk with facts some misconceived notions surrounding them.  Also, to raise awareness of the mainstream media’s desire to sell newspapers, gain website traffic or viewership by using racy headlines and inflammatory articles, over the need to unbiasedly educate the general populace.

  • Peptides Are Dangerous And Possibly Deadly – There is NO scientific or even ancillary evidence that supports this assertion. Unfortunately, news organizations get higher readership from headlines such as “Illegal Peptides May Be Fatal” than headlines like “Peptides May Help Millions of People”. In fact, there have been dozens of studies performed worldwide involving peptides and the worst known side effects when ingested by human participants were nausea, flushing, fever, increased libido and intense erections.  That doesn’t sound deadly, unless you ‘re a girl on the receiving end of that side effect.
  • A Woman Died in a Tanning Bed After Using MT-2 – This story is TRUE! Well, sort of… A woman did die in a tanning bed in England and yes authorities found she had Melanotan 2 in her system.  However, the autopsy revealed that she died from heart failure linked to obesity.  Also, that visit was her third visit in three days to the tanning bed (Sunbed death not linked to banned tanning jabs, n.d.).  Melanotan 2 had NOTHING to do with her unfortunate demise; it was merely a coincidence.  As a matter of fact, there was a recorded case (NCBI.nlm.nih.gov, n.d.) of a gentleman ingesting ten to twenty times the amount used in case studies and he did become slightly ill suffering nausea, vomiting and sympathomimetic excess and rhabdomyolysis.  He went to the hospital and after an I.V. treatment was released 3 days later.  According to the NCBI report, he also tested positive for opiates in his system so determining the cause of illness is impossible. Matter of fact, If you take ten-twenty times the dose of just about any over the counter drug, I imagine you’d experience similar illness or far worse.  Take 40 Aspirin and see how your stomach lining fairs.
  • Peptides Must Be Refrigerated At All Times – Most peptides are sold in a lyophilized state (that is simply a fancy word for freeze dried). In this state, they are presumed stable for up to approximately two years.  Once the peptide is reconstituted (that’s a fancy word for mixed with water or a sterile solution of some sort) then the mixture begins to breakdown and it is recommended the peptide be refrigerated to help maintain its chemical structure.  It’s said that once refrigerated the peptide will retain its integrity for up to 6 months.  Therefor refrigeration is recommended once reconstituted but unnecessary prior.

lyophilized vials MT-2

 

  • Mannitol Is Bad Or Is A Sign Of Low Quality Peptides – Not True and not sure how this rumor got started. Perhaps because when ingested in fairly large quantities it may cause diarrhea.  Or because of its appearance it’s a popular substance to cut illegal drugs like cocaine.  (Sorbitol vs. Mannitol, n.d.)Mannitol is a sugar substitute manufactured from fructose of corn starch and is used only to give the appearance of more substance in a vial.  That’s it.  I suppose if unscrupulous companies are making fake peptides and using mannitol as a substitute, then that is obviously bad.  Most labs however, add it to peptides that are under 5 mg to give them a look of having a little more in the vial, WITHOUT negatively altering the actual amount of the peptide.  Otherwise the vial looks so empty some researchers may be under the assumption they have been ripped off.  Also, the addition of sucrose or mannitol has been known to help stabilize the peptide (NCBI.gov, n.d.)
  • They’re Unapproved Or Banned Worldwide – Truth is many peptides have been approved and are currently available by prescription in many countries including Australia, Italy and Switzerland that have recognized their potential for a variety of applications. Other countries including the US have granted Phase III approval (ClinicalTrials.org, n.d.) for testing of many peptides and it would seem it’s only a matter of time before they gain approval.

World Wide Melanotan 2

  • Peptides Are Not FDA Approved Therefore They Are Unsafe – Well, there is some truth to this, if they’re not FDA approved, then perhaps there is a safety concern involving the use of peptides. Furthermore, and just as important, in the US the ingestion of peptides are illegal due to the fact they are considered drugs and there is still a need for more tests to exam their long term effects on humans.  Having said that, consider that most of the supplements in your local big name supplement store are not FDA approved but they’re protected under the Dietary Supplement Health and Education Act of 1994. Therefore millions of Americans ingest products that are NOT FDA approved and seem to gain benefits from such products, myself included.  It’s estimated that the supplement business is a 35 billion dollar a year business.  Seems as though a lot of people are ingesting things not approved by the FDA and not dropping dead.
  • Nasal Sprays Are An Alternative Method Of Administering Melanotan 2 – When trying to get a drug approved, it is estimated that about 90% of all drugs don’t make it due to safety risks, side effects, lack of funding, miniscule potential for profitability, etc. Peptides in general are considered to be poor drug candidates for FDA approval due to their low oral bioavailability and their lack of potential profits (Vlieghe, Lisowski, Martinez, & Khrestchatisky, n.d.).  Therefore alternative methods of administering the drugs have been explored in hopes of a more acceptable means rather than injecting.  In this endeavor, scientist created a nasal spray of Melanotan 2 for this purpose.  However, after studies were performed, it was determined that the particles of the peptide were too large to be properly absorbed through the membranes in the nasal passage rendering the drug ineffectual.  Also, due to the method of ingestion, increased blood pressure and heart rate was observed in most candidates.   This was not the case with candidates from the injected trials.  Therefor the nasal sprays have been abandoned and sites selling them online should be avoided.

Nothing in this article is meant to be construed as legal advice nor is it an advertisement or promotion of any kind to recreationally ingest peptides.  Peptides are still not FDA approved in the US and therefore it is illegal to ingest them.  Any opinions provided here are for informational purposes only.

Peptides for the advancement of research can be found at the Peptide Pros Shop

References

ClinicalTrials.org. (n.d.). Retrieved from ClinicalTrials.org: http://clinicaltrials.gov/ct2/show/NCT01605136?term=afamelanotide&rank=8

NCBI.gov. (n.d.). Retrieved from NCBI.gov: http://www.ncbi.nlm.nih.gov/pubmed/15986465

NCBI.nlm.nih.gov. (n.d.). Retrieved from NCBI.nlm.nih.gov: http://www.ncbi.nlm.nih.gov/pubmed/15986465

Sorbitol vs. Mannitol. (n.d.). Retrieved from Livestrong.com: http://www.livestrong.com/article/521615-sorbitol-vs-mannitol/

Sunbed death not linked to banned tanning jabs. (n.d.). Retrieved from BBC.com: http://www.bbc.com/news/uk-england-lancashire-22284433

Vlieghe, P., Lisowski, V., Martinez, J., & Khrestchatisky, M. (n.d.). Synthetic Therapeutic Peptides: Science and Market. Retrieved from drugdiscoverytoday.com: http://www.drugdiscoverytoday.com/download/534